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Scientific Program

September, 29

September, 30

October, 01

October, 02

Açores Room
14:00 - 18:00Registration
18:00 - 18:30Opening Ceremony
18:30 - 19:00SBI Women in Science Award
19:00 - 20:00Opening Conference
Chair: Claudia Brodskyn
Lieping Chen
Tumor microenvironment as a target of immunotherapy
20:00 - 22:00Cocktail
Pico RoomIlha RoomSão Miguel RoomFlores Room
7:30 - 8:30BD Biosciences course in Immunotherapy
Iris Castro

High dimension cell-Analysis in immunotherapy: FlowJo Supporting your Discoveries
8:30 - 9:00BreakBreakBreakBreak
9:00 - 11:00Symposium in Immunotherapeutical
intervention on leukocyte trafficking

Chair: Loic Dupré
Symposium in Metabolic regulation in immune cells
Chair: José Alves Filho
Extra Section of Clinical Immunology (ESCI) Joint Symposium with the Brazilian Society of Clinical Oncology (SBOC) in Cancer immunotherapy
Chair: Carlos Gil Ferreira
Symposium The multiple dimensions of immunology: A tribute to George Alexandre dos Reis
Chair: Marcello Barcinski
9:00 - 9:30Emmanuel Donnadieu
Imaging CAR-T cell migration in tumors
Kelly Magalhães
Adipose organ plasticity and cancer modulation
Eliane Piaggio
Immune landscape of rhabdoid tumors: Non-
genetic mechanisms of
tumor immunogenicity
Adriana Bonomo
From self-recognition to cancer immunobiology
9:30 - 10:00Lisa Westerberg
Targeting actin regulators in cancer therapy
Luciana Berod
Metabolic regulation of Treg cells
Ricardo Weinlich
RIPK3 is an overall survival predictor and is
associated with altered immunemodulation in
lower grade glioma patients
Maria Bellio
The CD4 T cell response during infection
by Trypanosoma cruzi
10:00 - 10:30Gustavo Menezes
Your liver may be sick, and you do not know: imaging the immune system during asymptomatic steatosis
Niels Olsen Saraiva Camara
Sirtuin 1 and cell metabolism in innate and adaptive cells
Andreia Melo
Evolving paradigms in melanoma therapy
Marcela Lopes
Efferocytosis by TAM receptors in
macrophage-mediated immunity to Trypanosoma cruzi
10:30 - 11:00Jens Stein
CD8+ T cell immune surveillance of non-lymphoid tissue
Jeff Rathmell
Fueling T cells in inflammation and cancer
Kenneth Gollob
Immunoregulatory mechanisms associated
with failure of checkpoint inhibitor immunotherapy in cancer
Alessandra Filardy
Efferocytosis mediated by TAM receptors modulates lung mucosae homeostasis
11:00 - 11:30Coffee BreakCoffee BreakCoffee Break
11:30 - 12:30Morning conference
Chair: Vinicius Cotta de Almeida
Morning conference
Chair: Patricia Bozza
Extra Section of Clinical Immunology (ESCI) Morning conference
Chair: Cristina Bonorino
Minsoo Kim
Initiation and resolution of neutrophil response during infection
Tim Sparwasser
Metabolic checkpoints controlling immune cell function
Enfu Hui
How anti-PD-1 differs from anti-PD-L1: A
cell biology perspective
12:30 - 15:30LunchLunchLunch
12:30 - 14:00Backman-Coulter symposium
Olindo Assis Martins Filho and Andréa Teixeira de Carvalho

Instituto René Rachou, Fiocruz
Characterization of circulating
microvesicles in sepsis and infectious endocarditis patients
BD Biosciences symposium
Robert Balderas

VP for Biological Sciences
High-dimensional analysis of single cells: The path to 50 parameter and beyond
José de Moura Leite Netto
Brazilian Network of Journalists and Science
The power of science popularization
14:00 - 15:30BreakBreakBreak
15:30 - 17:00Express presentation in
Innate immunity

Chair: Flavia Carneiro
Express presentation in Signaling and molecular immunology
Chair: Eugenio Hottz
Express presentation in
Inflammation and immunopharmacology

Chair: Josiane Neves
15:30 - 15:52Flavia Carneiro
An essential role for ECSIT in mitochondrial
complex I assembly and mitophagy in macrophages
Eugenio Hottz
Beyond LPS sensing: TLR-4-induced platelet activation by DENV NS1 and circulating extracellular histones in dengue
Josiane Neves
Inflammation and extracellular DNA traps: Untangling a tangle-web
15:52 - 16:09Camila Meirelles de Souza Silva
Caspase 11/Gasdermin D-dependent netosis
plays a vital role in the inflammation and organ damage during sepsis
Axel Fogaça Rosado
NLRP3 inflammasome inhibition counteracts behavioural, neurochemical and
neuroinflammatory modifications induced
by chronic stress in female mice
Julia Góes Porfirio
Evaluation of the role of 12(S)-Hete in vascular leakage in Dengue fever
16:09 - 16:26Barbara Simonson Gonçalves
Neutrophil extracellular traps from healthy
donors and from HIV-1-infected patients restrain HIV-1 infection in macrophages
Bárbara Costa Peixoto
Role of the transcriptional co-factor
IRF2BP2 in Th1 cell polarization and IFN-γ expression
Vívian Louise Soares de Oliveira
FcγRIIγ And FcγRIII have opposite functions
in controlling bacterial clearance and joint
inflammation in Staphylococcus Aureus-induced arthritis
16:26 - 16:43Anna Julia Pietrobon
Inhibition of HIV-I replication in neonatal
macrophages by IFN-I adjuvants
Carlos Arterio Sorgi
Tumour microenvironment metabolites induced modulation of macrophage activity
and reprogram lipid metabolism
Gabriel Azevedo Publio
Metabolic reprogramming plays a critical role in IL-17α driven keratinocyte activation in psoriasis through NFkB-pathway mechanism
16:43 - 17:00Ana Carolina Guerta Salina
Skin resident macrophage-derived
microRNA21 drives susceptibility to
Staphylococcus aureus infection
Guilherme Afonso Melo
The epigenetic modulator Prc1 in CD8 T cell differentiation
Lohanna Palhinha do Amaral
Leptin induces proinflammatory and pro-adipogenic signalling in adipocytes
17:00 - 18:00Twilight conference
Chair: Gustavo Amarante-Mendes
Twilight conference
Chair: Lucas Carvalho
Extra Section of Clinical Immunology (ESCI)
Twilight conference

Chair: Ana Paula Lepique
Mark Ansel
Molecular regulation of tissue immunity
Mauro Teixeira
Immunotherapy with drugs that induce the resolution of inflammation
Luisa Villa
Pathways to the elimination of HPV-induced cancer
18:00 - 18:30Coffee BreakCoffee BreakCoffee Break
Açores Room
18:30 - 19:30Keynote conference
Chair: Helder Nakaya
Rafi Ahmed
T cell exhaustion and PD-1 immunotherapy
Cascaes Room
Pico RoomIlha RoomSão Miguel RoomFlores Room
7:30 - 8:30BD Biosciences course in Immunotherapy
Flavia Calmon

High dimension cell-Analysis in immunotherapy: Experiment design matters
8:30 - 9:00BreakBreakBreak
9:00 - 11:00Symposium in T cell activation and exhaustion
Chair: André Vale
Symposium in Immunoregulation
Chair: Marcelo Bozza
Extra Section of Clinical Immunology (ESCI) Joint Symposium with the Brazilian Society of Rheumatology (SBR) in Autoimmune diseases
Chair: Eduardo Paiva
9:00 - 9:30Renata Meireles
Control of CD8 T cell differentiation by polycomb group proteins
Claudia Benjamim
Can a protein cannabinoid be a future
treatment for sepsis and its late consequences
Luis Eduardo Coelho Andrade
Pre-autoimmunity: A unique opportunity for
understanding and modulating autoimmune diseases
9:30 - 10:00Alice Kamphorst
Costimulation and CD8 T cell exhaustion
Ana Paula Lepique
Interplay between STAT3 and p6 NFkappaB modulates T cell anti-tumor immune responses
Paulo Louzada Júnior
Innate immune response as a therapeutic target in autoimmune diseases
10:00 - 10:30Ben Youngblood
T-cell intrinsic and extrinsic mechanisms limiting tumor immunotherapy
Daniel Mansur
ISG15 is a circumstantial antiviral protein
Denise Fonseca
Acute mucosal infection imposes a long-term remodeling of host metabolism in a microbiota-dependent manner
10:30 - 11:00Peter Sage
Regulation of B cell responses by follicular T cells
Bernardo Franklin
Platelets fuel the inflammasome activation of innate immune cells
Mary Keir
The immune response in inflammatory bowel
11:00 - 11:30Coffee BreakCoffee BreakCoffee Break
11:30 - 12:30Morning conference
Chair: Moises Bauer
Morning conference
Chair: Julio Scharfstein
Extra Section of Clinical Immunology (ESCI)
Morning conference

Chair: Ana Caetano de Farias
Graham Pawelec
Ageing and the human immune system
Francesca Granucci
Ca2+ regulated pathways downstream of pattern recognition receptors
Scott Snapper
Cytokines, cytokine signaling and inflammatory bowel disease: Novel mechanisms and therapeutic implications
through the study of rare diseases
12:30 - 15:30LunchLunchLunch
12:30 - 14:00Satellite symposiumSBI-BD Biosciences investigator award
Finalist oral presentation
José de Moura Leite Netto
Brazilian Network of Journalists and Science Communicators
The power of science popularization
14:00 - 15:30BreakBreakSBI Thereza Kipnis Award
Chair: Lis Antonelli
15:30 - 17:00Express presentation in
Immunity to infection and host defense

Chair: Pritesh Lalwani
Express presentation in Cellular and mucosal immunology
Chair: Bernado Reis
15:30 - 15:52Pritesh Lalwani
IDO-AHR axis: Vivax malaria
Bernado Reis
The role of intraepithelial lymphocytes in colon cancer
14:00 - 14:30
Camila R.R. Barbosa
New malaria vaccine candidates: identification and validation of peptides presented by HLA-I in reticulocytes infected with Plasmodium vivax using immunopeptidomics
15:52 - 16:09Cecilia Bataglioli Cavazzoni
B cell subsets and immunoglobulin
repertoire dynamics during Zika virus
experimental infection
Rafaela Mano Guimarães
Blood-circulating leukocytes fail to
infiltrate the spinal cord and dorsal root ganglia parenchyma after spared nerve injury
14:30 - 15:00
Luis Eduardo A. Damasceno
The glycolytic enzyme PKM2 promotes Th17
cell development and mediated autoimmune inflammation
16:09 - 16:26Beatriz Macedo de Oliveira Rocha
Associations between obesity and gut
microbiota during experimental tuberculosis: impact on lipid metabolism
Anna Cecíllia Quirino Teixeira
Dengue virus non-structural protein 1
activates platelets and induces secretion of
proinflammatory mediators partially through TLR4
15:00 - 15:30
Brenda Naemi Nakagaki
Immune and metabolic shifts during
neonatal development reprogram liver
identity and function
16:26 - 16:43Julia da Cunha Santos
Mechanisms of lipid droplets biogenesis in
macrophages infected by Escherichia Coli
Fernando Bandeira Sulczwski
STAT6 Signaling pathway modulates follicular helper T cell fate and germinal center formation in immune responses promoted by type 2 conventional dendritic cells
15:30 - 16:00
Gretel R. Rodríguez
Control of STAT-3 and NF-kB signaling by
IL-6 and G-CSF in local and systemic immune response in HPV tumor bearing hosts
16:43 - 17:00 Luísa Menezes Silva
Omentum as a new component of the
mucosal firewall
Maria Tereza Martinez
The influence of ketogenic diet in gut immune homeostasis
16:00 - 16:30
Maria Claudia da Silva
Canonical PI3Kγ signaling in myeloid
cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis
17:00 - 18:00Twilight conference
Chair: Roque Pacheco
Twilight conference
Chair: Dario Zamboni
Twilight conference
Chair: Camila Indiani
Edgar de Carvalho
Use of topical imunomodulators in the
therapy of cutaneous Leishmaniasis
Fernando Cunha
Do neutrophil extracellular traps (NETs) play a relevant role in the pathology of inflammatory diseases?
Walderez Dutra
Using immunoregulatory networks to instruct therapeutic interventions in human parasitic diseases
18:00 - 18:30Coffee BreakCoffee BreakCoffee Break
Açores Room
Cascaes Room
19:30 - 22:00Poster Session with Happy Hour
Pico RoomIlha RoomSão Miguel RoomFlores Room
7:30 - 8:30BD Biosciences course in Immunotherapy
Lucas Rizzo

High dimension cell-Analysis in immunotherapy: Expanding cell boundaries by integrating sorting and transcriptome
8:30 - 9:00BreakBreakBreak
9:00 - 11:00Joint Symposium with the Society for Leukocyte Biology (SLB) in Target
leukocyte for immunotherapy

Chair: Martin Bonamino
Symposium in Vaccines
Chair: Helder Nakaya
Extra Section of Clinical Immunology (ESCI)
Joint Symposium with the Brazilian Association of Allergy and Immunology

(ASBAI) in Allergic diseases
Chair: Edecio Cunha-Neto
9:00 - 9:30Miriam Werneck
In vitro differentiated memory cells as a tool for immunotherapy
Ricardo Palacios
Dengue vaccine immune response: Between wishful thinking and good enough
João Negreiros Tebyriçá
Allergy Immunotherapy: Immunological mechanisms and clinical indications
9:30 - 10:00Marco Davila
Mutation of the CD28 endodomain confers resistance of CAR-T cells to exhaustion
Olindo Martins Filho
Impact of synthetic and
biological immunotherapy on the duration of immunity induced by the 17DD yellow fever vaccine
Pedro Giavina Bianchi
Immunomodulation of type 2 inflammation
with monoclonal antibodies
10:00 - 10:30Sven Brandau
Tumor-associated neutrophils: Mediators of
tumor progression and targets for combination immunotherapy
Esper Kallas
Development of vaccines to prevent Zika
Momtchilo Russo
Specific immunotherapy associated with TLR9 agonist for experimental asthma
10:30 - 11:00Jose Conejo-Garcia
Coordinated T and B cell responses spontaneously protect against ovarian cancer progression
Daniela Ferreira
Experimental human pneumococcal
challenge for vaccine development
Caroline Sokol
Innate control of allergic immunity: New players, new pathways
11:00 - 11:30Coffee BreakCoffee BreakCoffee Break
11:30 - 12:30Morning conference
Chair: João Trindade Marques
Morning conference
Chair: Karina Bortoluci
Extra Section of Clinical Immunology (ESCI)
Morning conference

Chair: Lis Antonelli
Rosa Bacchetta
Lentiviral-mediated gene transfer to convert T cells into Treg cells: New generation immune therapies
Ricardo Gazzinelli
The circadian cycle and malaria: The sweet side of the story
Irini Sereti
Idiopathic CD4 lymphopenia: A new kid on the autoimmunity block?
12:30 - 15:30LunchLunchLunch
12:30 - 14:00SBI general assembly
Satellite symposiumSatellite symposium
14:00 - 15:30BreakBreakBreak
15:30 - 17:00Express presentation in
Tumor and clinical immunology

Chair: Rodrigo Ramos
Express presentation in
Immuneregulation in diseases

Chair: Larissa Cunha
Express presentation in
Immunotherapy and vaccine

Chair: Eduardo Lani Silveira
15:30 - 15:52Rodrigo Ramos
Unrevealing tumor-associated macrophages
heterogeneity in breast cancer patients
Larissa Cunha
The role of autophagy in the functional polarization of tumor-associated macrophages
Eduardo Lani Silveira
Tryptophan metabolism drives the Dengue
virus-mediated B cell differentiation into
antibody-secreting cells
15:52 - 16:09Murillo Duarte Silva
The use of biologicals in top-down approach:
a more promising strategy to induce remission and inflammation control in
Crohn’s disease patients under anti-TNF therapy
Camila Figueiredo Pinzan
Melatonin treatment restores the balance
between activated and regulatory responses
in intestinal immunity during experimental
Toxoplasma Gondii infection
Alexandre de Magalhães Vieira Machado
Assessment of the protective efficacy of a
vaccine based on a recombinant influenza virus against S. Pneumoniae
16:09 - 16:26Glauco Akelinghton Freire Vitiello
Identification of MMTV-env sequences in
Brazilian breast cancer patients and in silico
predicted epitopes from MMTV Env protein as potential immunogenic targets
Cristhiane Favero de Aguiar
Tissue-specific regulation of NKT cell
metabolism drives their function and contributes to obesity
Isaú Henrique Noronha
Intranasal vaccine against Trypanosoma cruzi mediates antibody protective responsi
16:26 - 16:43Luciana Rodrigues Carvalho Barros
Three-compartment mathematical model
CAR-T cell immunotherapy
Renato da Silva Cardoso
Relationship between cholinergic anti-inflammatory pathway and wound healing process: a perfect match?
Victória Alves Santos Lunardelli
Immunization with different ZIKV envelope
proteins induces long-term humoral and
cellular immunity in mice
16:43 - 17:00Nayara Gusmão Tessarollo
Down-regulation of neoantigens promoted
by treatment of B16F10 cells with P19ARF and IFN-
Wesley Nogueira Brandão
NMDA ionotropic receptor signalling on
the ontogeny of T-lymphocytes and its
repercussion in the development of experimental autoimmune encephalomyelitis
João Pedro da Silva Nunes
Assessment of the immunogenicity of the
leptospiral Lipl32, ligani, and ligbrep recombinant proteins in the sheep model
17:00 - 17:30Coffee BreakCoffee BreakCoffee Break
Açores Room
CHAIR: Ricardo Gazzinelli
18:30 - 19:00Awards announcement and Closing remarks
Cascaes Room
21:00Farewell party

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Est. Ver. Onildo Lemos, 2505 - Praia do Santinho - Florianópolis, SC

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Phone: +55 11 3034-2632